Fig. 5

Age of manifestation of cancer depending on the location and functional type of mutation. LOF ± – presence or absence of the loss of function effect according to Giacomelli et al. [17], NF is a non-functional variant, PF is a partially functional variant according to data from [18]. The majority of mutations in the TP53 gene identified in our study are classified as LOF + /NF. LOF—/PF mutations were detected in 5 patients (P05, P06, P07, P11, P12). Given the wide age range at manifestation for each functional mutation type, this parameter does not allow to perform precise prognosis for a specific carrier. However, it may be valuable for assessing the clinical significance of the variant and evaluating the risk of early manifestation of cancer in a family