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Fig. 1 | Hereditary Cancer in Clinical Practice

Fig. 1

From: Assessing germline TP53 mutations in cancer patients: insights into Li-Fraumeni syndrome and genetic testing guidelines

Fig. 1

Structure of the TP53 gene and different isoforms of the p53 protein. The N-terminal domains TAD1 and TAD2 (transactivation domain) are required for the activation of functionally related p53 target genes. The PXXP domain (proline-rich domain) plays an important role in the apoptotic activity of p53. The DNABD domain (DNA-binding domain, DNA-binding domain, “zinc finger”) directly interacts with DNA. NLS (nuclear localization domain) is a nuclear localization domain, OD (oligomerization domain) is an oligomerization (tetramerization) domain, NEG (negative-regulation domain) is a negative regulation domain that ensures the detachment of DNABD from DNA

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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287