Table 3 Results from association studies in all familial CRC (cases A) and sub-cohort of families with colorectal-, gastric- and prostate cancer (cases B)
Locus | SNP | Gene | Type | Ref | Alt | Cases A | Controls | OR | p | Cases B | OR | p |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
3q29 | rs181290971 | PCYT1A | 3' UTR | G | A | 808 | 1510 | 0.83 | 0.66 | 283 | 1.06 | 0.90 |
3q29 | rs41299376 | TFRC | 3' UTR | T | A | 819 | 1526 | 1.25 | 0.26 | 293 | 1.61 | 0.07 |
3q29 | rs754397679 | PCYT1A | missense | C | T | 785 | 1447 | 0 | 0 | 284 | 0 | 0 |
4q26 | rs141180741 | SEC24D | missense | G | A | 818 | 1514 | 0.83 | 0.66 | 293 | 1.08 | 0.82 |
4q26 | rs184578242 | METTL14 | 3' UTR | A | G | 819 | 1527 | 0.51 | 0.12 | 293 | 0.62 | 0.43 |
4q26 | rs35392900 | SEC24D | missense | G | C | 813 | 1505 | 0.87 | 0.64 | 292 | 1.14 | 0.72 |
4q35.1 | rs73872825 | ENPP6 | intron | A | G | 811 | 1473 | 1.14 | 0.50 | 292 | 1.06 | 0.85 |
13q13 | rs118015060 | SMAD9 | 3' UTR | A | G | 819 | 1527 | 1.02 | 0.92 | 293 | 1.39 | 0.27 |
13q33.3 | rs56393169 | MYO16 | 3' UTR | T | C | 819 | 1526 | 1.08 | 0.51 | 293 | 1.24 | 0.19 |
16q23.3 | rs72807847 | CDH13 | missense | A | G | 819 | 1527 | 1.40 | 0.37 | 293 | 1.63 | 0.33 |