From: Blood molybdenum level as a marker of cancer risk on BRCA1 carriers
Variables | Ovarian cases/total | Univariate HR (95%CI) P | Multivariate* HR (95%CI) P |
---|---|---|---|
Molybdenum level (µg/l) | |||
≤ 0.53 0.53–0.69 > 0.69 Total | 3/250 6/251 17/253 26/754 | 1 1.94 (0.49–7.78) 0.35 5.36 (1.51–18.3) 0.007 | 1 2.34 (0.57–9.64) 0.24 5.55 (1.59–19.4) 0.007 |
Year of birth | |||
≤ 1965 1965.01–1975 1975.01–1985 > 1985 | 9/95 8/156 8/321 1/182 | 1 0.50 (0.19–1.30) 0.15 0.25 (0.10–0.64) 0.004 0.06 (0.01–0.50) 0.009 | 1 1.08 (0.03–38.2) 0.97 0.34 (0.01–15.6) 0.58 0.08 (0.00-5.7) 0.25 |
Age at blood draw (years) | |||
≤ 40 40.01-50 > 50 | 12/539 5/124 9/91 | 1 1.81 (0.64–5.13) 0.27 4.70 (1.98–11.2) 0.0004 | 1 1.57 (0.13–2.42) 0.44 1.21 (0.03–53.8) 0.92 |
Oral contraceptive use | |||
No Yes | 16/359 10/394 | 1 0.54 (0.25–1.20) 0.13 | 1 0.92 (0.38–2.24) 0.86 |
Hormone Replacement Therapy | |||
No Yes | 23/601 3/152 | 1 0.44 (0.13–1.48) 0.19 | 1 0.35 (0.10–1.20) 0.10 |
Smoking history | |||
Never Current Former | 11/436 6/170 9/148 | 1 1.40 (0.52–3.79) 0.51 2.53 (1.05–6.12) 0.04 | 1 1.38 (0.50–3.80) 0.53 2.40 (0.96–5.97) 0.06 |
BMI at date of blood draw (kg/m2) | |||
≤ 23.0 > 23.0 | 10/385 15/333 | 1 1.74 (0.78–3.87 )0.18 | 1 1.09 (0.44–2.68) 0.55 |