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Table 2 Hazard ratios for breast cancer according to molybdenum level

From: Blood molybdenum level as a marker of cancer risk on BRCA1 carriers

Variables

Breast cases/total

Univariate

HR (95%CI) P-value

Multivariate*

HR (95%CI) P-value

Molybdenum level (µg/l)

   

≤ 0.53

0.53–0.70

> 0.70

30/317

36/319

48/321

1

1.12 (0.69–1.82) 0.65

1.46 (0.92–2.30) 0.11

1

1.13 (0.69–1.85) 0.63

1.46 (0.91–2.33) 0.12

Year of birth

   

≤ 1965

1965.01–1975

1975.01–1985

> 1985

34/230

25/215

43/330

12/182

1

0.81 (0.48–1.35) 0.42

0.95 (0.61–1.50) 0.83

0.56 (0.29–1.08) 0.09

1

0.81 (0.31–2.11) 0.67

1.01 (0.28–3.72 )0.98

0.56 (0.14–2.28) 0.41

Age at blood draw (years)

   

≤ 40

40.01-50

> 50

59/549

26/208

29/200

1

1.12 (0.71–1.78) 0.62

1.24 (0.79–1.94) 0.34

1

1.66 (0.65–4.25) 0.29

1.67 (0.45–6.24) 0.45

Oophorectomy

   

No

Yes

27/393

87/564

1

0.83 (0.57–1.21) 0.33

1

0.61 (0.37-1.00) 0.05

Oral contraceptive use

   

No

Yes

53/485

61/471

1

1.17 (0.81–1.69) 0.40

1

1.28 (0.86–1.90) 0.23

Hormone replacement therapy

   

No

Yes

83/697

31/259

1

0.87 (0.58–1.32) 0.51

1

0.86 (0.54–1.35) 0.50

Smoking history

   

Never

Current

Former

54/539

33/215

27/203

1

1.60 (1.04–2.47) 0.03

1.33 (0.84–2.12) 0.22

1

1.62 (1.05–2.51) 0.03

1.31 (0.82–2.10) 0.26

BMI at date of blood draw

   

≤ 23.0

> 23.0

57/450

54/470

1

0.88 (0.60–1.27) 0.49

1

0.85 (0.57–1.27) 0.43

  1. * adjusted by all the variables listed in the left column