Fig. 1
From: Current prospects of hereditary adrenal tumors: towards better clinical management
Molecular features and molecularly targeted agents for druggable genes in adrenal tumors. ACC from the adrenal cortex and PPGL from the adrenal medulla have different molecular features. The major molecular cascades are p53/Rb and Wnt/β-catenin pathways for ACC, and pseudohypoxia, kinase signaling, and Wnt signaling pathways for PPGL. The treatment types differ depending on the mutated genes present, such as HIF-2α inhibitors for pseudohypoxia-associated PPGL