Whole-body MRI within a surveillance program for carriers with clinically actionable germline TP53 variants - the Swedish constitutional TP53 study SWEP53

Table 2 The Toronto and the SWEP53 protocol for adults

The Toronto protocol (2011) Adults	Breast cancer	Brain tumor	Soft tissue and bone sarcoma	Leukaemia or lymphoma	Colon cancer	Melanoma
	Monthly breast self-examination starting at age 18 years	Annual brain MRI	Annual rapid total body MRI	Blood test every 4 months: complete blood count, erythrocyte sedimentation rate, lactate dehydrogenase	Colonoscopy every 2 years, beginning at age 40 years, or 10 years before the earliest known colon cancer in the family	Annual dermatological examination
	Clinical breast examination twice a year, starting at age 20–25 years, or 5–10 years before the earliest known breast cancer in the family		Ultrasound of abdomen and pelvis every 6 months
	Annual mammography and breast MRI screening starting at age 20–25 years, or at earliest age of onset in the family
	Consider risk-reducing bilateral mastectomy
The SWEP53 Protocol Adults	Breast cancer	Brain tumor	Soft tissue and bone sarcoma	Leukemia or lymphoma	Colon cancer	Melanoma
	Monthly breast self-examination starting at age 18 years	Annual brain MRI	Whole-body MRI	Only if there are known cases in the family	Only if there are known cases in the family. 10 years before the earliest known colon cancer in the family	Annual dermatological examination
	Clinical breast examination once a year, starting at age 18
	Annual breast MRI screening starting at age 18 and breast ultrasounds 6 month after the MRI
	Consider risk-reducing bilateral mastectomy

ISSN: 1897-4287